Experts in the production and differentiation of iPSCs

The team behind Newcells was one of the first to use iPSC technology in the UK and is at the core of one of the main centres of reprogramming in Europe

Published papers

Published papers for Prof Lyle Armstrong and Prof Majlinda Lako.


Aging of stem and progenitor cells: mechanisms, impact on the therapeutic potential and rejuvenation.

Nurkovic JS, Volarevic V, Lako M, Armstrong L, Arsenijevic N, Stojkovic M.

Rejuvenation Res. 2015 Jun 9. [Epub ahead of print]

PMID: 26055182


Concise Reviews: Cardiac Disease Modeling Using Induced Pluripotent Stem Cells.

Yang C, Al-Aama J, Stojkovic M, Keavney B, Trafford A, Lako M, Armstrong L.

Stem Cells. 2015 May 28. doi: 10.1002/stem.2070. [Epub ahead of print]

PMID: 26033645


Generation of Human Induced Pluripotent Stem Cells Using RNA-Based Sendai Virus System and Pluripotency Validation of the Resulting Cell Population.

Chichagova V, Sanchez-Vera I, Armstrong L, Steel D, Lako M.

Methods Mol Biol. 2015 Feb 20. [Epub ahead of print]

PMID: 25697416


Engraftment's Holy Grail: is one signal enough?

Lako M, Armstrong L.

Blood. 2014 Nov 13;124(20):3035-6. doi: 10.1182/blood-2014-09-600452.

PMID: 25395139


Concise review: the epigenetic contribution to stem cell ageing: can we rejuvenate our older cells?

Armstrong L, Al-Aama J, Stojkovic M, Lako M.

Stem Cells. 2014 Sep;32(9):2291-8. doi: 10.1002/stem.1720.

PMID: 24740867


An induced pluripotent stem cell model of hypoplastic left heart syndrome (HLHS) reveals multiple expression and functional differences in HLHS-derived cardiac myocytes.

Jiang Y, Habibollah S, Tilgner K, Collin J, Barta T, Al-Aama JY, Tesarov L, Hussain R, Trafford AW, Kirkwood G, Sernagor E, Eleftheriou CG, Przyborski S, Stojković M, Lako M, Keavney B, Armstrong L.

Stem Cells Transl Med. 2014 Apr;3(4):416-23. doi: 10.5966/sctm.2013-0105. Epub 2014 Mar 3.

PMID: 24591732


Brief report: a human induced pluripotent stem cell model of cernunnos deficiency reveals an important role for XLF in the survival of the primitive hematopoietic progenitors.

Tilgner K, Neganova I, Singhapol C, Saretzki G, Al-Aama JY, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M.

Stem Cells. 2013 Sep;31(9):2015-23. doi: 10.1002/stem.1456.

PMID: 23818183


A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors.

Tilgner K, Neganova I, Moreno-Gimeno I, Al-Aama JY, Burks D, Yung S, Singhapol C, Saretzki G, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M.

Cell Death Differ. 2013 Aug;20(8):1089-100. doi: 10.1038/cdd.2013.44. Epub 2013 May 31.

PMID: 23722522


A novel model of urinary tract differentiation, tissue regeneration, and disease: reprogramming human prostate and bladder cells into induced pluripotent stem cells.

Moad M, Pal D, Hepburn AC, Williamson SC, Wilson L, Lako M, Armstrong L, Hayward SW, Franco OE, Cates JM, Fordham SE, Przyborski S, Carr-Wilkinson J, Robson CN, Heer R.

Eur Urol. 2013 Nov;64(5):753-61. doi: 10.1016/j.eururo.2013.03.054. Epub 2013 Apr 6.

PMID: 23582880


Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors.

Yung SK, Tilgner K, Ledran MH, Habibollah S, Neganova I, Singhapol C, Saretzki G, Stojkovic M, Armstrong L, Przyborski S, Lako M.

Stem Cells. 2013 May;31(5):1022-9. doi: 10.1002/stem.1308.

PMID: 23280624


A putative role for the immunoproteasome in the maintenance of pluripotency in human embryonic stem cells.

Atkinson SP, Collin J, Irina N, Anyfantis G, Kyung BK, Lako M, Armstrong L.

Stem Cells. 2012 Jul;30(7):1373-84. doi: 10.1002/stem.1113.

PMID: 22532526


Potential for pharmacological manipulation of human embryonic stem cells.

Atkinson SP, Lako M, Armstrong L.

Br J Pharmacol. 2013 May;169(2):269-89. doi: 10.1111/j.1476-5381.2012.01978.x. Review.

PMID: 22515554


Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease.

Jiang Y, Cowley SA, Siler U, Melguizo D, Tilgner K, Browne C, Dewilton A, Przyborski S, Saretzki G, James WS, Seger RA, Reichenbach J, Lako M, Armstrong L.

Stem Cells. 2012 Apr;30(4):599-611. doi: 10.1002/stem.1053.

PMID: 22311747


Editorial: Our top 10 developments in stem cell biology over the last 30 years.

Armstrong L, Lako M, Buckley N, Lappin TR, Murphy MJ, Nolta JA, Pittenger M, Stojkovic M.

Stem Cells. 2012 Jan;30(1):2-9. doi: 10.1002/stem.1007.

PMID: 22162299


Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.

International Stem Cell Initiative, Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Lu G, Hampl A, Harron K, Healy L, Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Sheik Mohamed J, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y, Ward-van Oostwaard D, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q.

Nat Biotechnol. 2011 Nov 27;29(12):1132-44. doi: 10.1038/nbt.2051.

PMID: 22119741


Large-scale transcriptional profiling and functional assays reveal important roles for Rho-GTPase signalling and SCL during haematopoietic differentiation of human embryonic stem cells.

Yung S, Ledran M, Moreno-Gimeno I, Conesa A, Montaner D, Dopazo J, Dimmick I, Slater NJ, Marenah L, Real PJ, Paraskevopoulou I, Bisbal V, Burks D, Santibanez-Koref M, Moreno R, Mountford J, Menendez P, Armstrong L, Lako M.

Hum Mol Genet. 2011 Dec 15;20(24):4932-46. doi: 10.1093/hmg/ddr431. Epub 2011 Sep 21.

PMID: 21937587


An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.

Neganova I, Vilella F, Atkinson SP, Lloret M, Passos JF, von Zglinicki T, O'Connor JE, Burks D, Jones R, Armstrong L, Lako M.

Stem Cells. 2011 Apr;29(4):651-9. doi: 10.1002/stem.620.

PMID: 21319273


Opposing putative roles for canonical and noncanonical NFκB signaling on the survival, proliferation, and differentiation potential of human embryonic stem cells.

Yang C, Atkinson SP, Vilella F, Lloret M, Armstrong L, Mann DA, Lako M.

Stem Cells. 2010 Nov;28(11):1970-80. doi: 10.1002/stem.528.

PMID: 20882529


Induced pluripotent stem cells : it looks simple but can looks deceive?

Lako M, Armstrong L, Stojkovic M.

Stem Cells. 2010 May;28(5):845-50. doi: 10.1002/stem.411. No abstract available.

PMID: 20235273


Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells.

Armstrong L, Tilgner K, Saretzki G, Atkinson SP, Stojkovic M, Moreno R, Przyborski S, Lako M.

Stem Cells. 2010 Apr;28(4):661-73. doi: 10.1002/stem.307.

PMID: 20073085


Expression of GFP under the control of the RNA helicase VASA permits fluorescence-activated cell sorting isolation of human primordial germ cells.

Tilgner K, Atkinson SP, Yung S, Golebiewska A, Stojkovic M, Moreno R, Lako M, Armstrong L.

Stem Cells. 2010 Jan;28(1):84-92. doi: 10.1002/stem.263.

PMID: 19937754


Epigenetic landscaping during hESC differentiation to neural cells.

Golebiewska A, Atkinson SP, Lako M, Armstrong L.

Stem Cells. 2009 Jun;27(6):1298-308. doi: 10.1002/stem.59.

PMID: 19489095


G1 to S transition and pluripotency: two sides of the same coin?

Lako M, Neganova I, Armstrong L.

Cell Cycle. 2009 Apr 15;8(8):1108-9. Epub 2009 Apr 26. No abstract available.

PMID: 19305136


A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A.

Zhang X, Neganova I, Przyborski S, Yang C, Cooke M, Atkinson SP, Anyfantis G, Fenyk S, Keith WN, Hoare SF, Hughes O, Strachan T, Stojkovic M, Hinds PW, Armstrong L, Lako M.

J Cell Biol. 2009 Jan 12;184(1):67-82. doi: 10.1083/jcb.200801009.

PMID: 19139263


Non-invasive imaging of stem cells by scanning ion conductance microscopy: future perspective.

Gorelik J, Ali NN, Sheikh Abdul Kadir SH, Lab M, Stojkovic P, Armstrong L, Sviderskaya EV, Negulyaev YA, Klenerman D, Bennett DC, Lako M, Harding SE, Stojkovic M, Korchev YE.

Tissue Eng Part C Methods. 2008 Dec;14(4):311-8. doi: 10.1089/ten.tec.2008.0058.

PMID: 19055357


Isolation of primordial germ cells from differentiating human embryonic stem cells.

Tilgner K, Atkinson SP, Golebiewska A, Stojkovic M, Lako M, Armstrong L.

Stem Cells. 2008 Dec;26(12):3075-85. doi: 10.1634/stemcells.2008-0289. Epub 2008 Sep 18.

PMID: 18802037


Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches.

Ledran MH, Krassowska A, Armstrong L, Dimmick I, Renström J, Lang R, Yung S, Santibanez-Coref M, Dzierzak E, Stojkovic M, Oostendorp RA, Forrester L, Lako M.

Cell Stem Cell. 2008 Jul 3;3(1):85-98. doi: 10.1016/j.stem.2008.06.001.

PMID: 18593561


Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells.

Stewart R, Yang C, Anyfantis G, Przyborski S, Hole N, Strachan T, Stojkovic M, Keith WN, Armstrong L, Lako M.

Regen Med. 2008 Jul;3(4):505-22. doi: 10.2217/17460751.3.4.505.

PMID: 18588473


Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells.

Maimets T, Neganova I, Armstrong L, Lako M.

Oncogene. 2008 Sep 11;27(40):5277-87. doi: 10.1038/onc.2008.166. Epub 2008 Jun 2.

PMID: 18521083


A putative role for RHAMM/HMMR as a negative marker of stem cell-containing population of human limbal epithelial cells.

Ahmad S, Kolli S, Li DQ, de Paiva CS, Pryzborski S, Dimmick I, Armstrong L, Figueiredo FC, Lako M.

Stem Cells. 2008 Jun;26(6):1609-19. doi: 10.1634/stemcells.2007-0782. Epub 2008 Mar 20.

PMID: 18356573


Epigenetic marking prepares the human HOXA cluster for activation during differentiation of pluripotent cells.

Atkinson SP, Koch CM, Clelland GK, Willcox S, Fowler JC, Stewart R, Lako M, Dunham I, Armstrong L.

Stem Cells. 2008 May;26(5):1174-85. doi: 10.1634/stemcells.2007-0497. Epub 2008 Feb 21.

PMID: 18292213


A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation.

Yang C, Przyborski S, Cooke MJ, Zhang X, Stewart R, Anyfantis G, Atkinson SP, Saretzki G, Armstrong L, Lako M.

Stem Cells. 2008 Apr;26(4):850-63. doi: 10.1634/stemcells.2007-0677. Epub 2008 Jan 17.

PMID: 18203676


Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells.

Saretzki G, Walter T, Atkinson S, Passos JF, Bareth B, Keith WN, Stewart R, Hoare S, Stojkovic M, Armstrong L, von Zglinicki T, Lako M.

Stem Cells. 2008 Feb;26(2):455-64. Epub 2007 Nov 29.

PMID: 18055443


The future of human nuclear transfer?

Armstrong L, Lako M.

Stem Cell Rev. 2006;2(4):351-8. Review. No abstract available.

PMID: 17848722


Differentiation of human embryonic stem cells into corneal epithelial-like cells by in vitro replication of the corneal epithelial stem cell niche.

Ahmad S, Stewart R, Yung S, Kolli S, Armstrong L, Stojkovic M, Figueiredo F, Lako M.

Stem Cells. 2007 May;25(5):1145-55. Epub 2007 Jan 25.

PMID: 17255521


Derivation of human embryonic stem cells from developing and arrested embryos.

Zhang X, Stojkovic P, Przyborski S, Cooke M, Armstrong L, Lako M, Stojkovic M.

Stem Cells. 2006 Dec;24(12):2669-76. Epub 2006 Sep 21.

PMID: 16990582


The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis.

Armstrong L, Hughes O, Yung S, Hyslop L, Stewart R, Wappler I, Peters H, Walter T, Stojkovic P, Evans J, Stojkovic M, Lako M.

Hum Mol Genet. 2006 Jun 1;15(11):1894-913. Epub 2006 Apr 27.

PMID: 16644866


Epigenetic modification is central to genome reprogramming in somatic cell nuclear transfer.

Armstrong L, Lako M, Dean W, Stojkovic M.

Stem Cells. 2006 Apr;24(4):805-14. Epub 2005 Nov 10. Review.

PMID: 16282443


Human embryonic stem cells: biology and clinical implications.

Hyslop LA, Armstrong L, Stojkovic M, Lako M.

Expert Rev Mol Med. 2005 Sep 19;7(19):1-21. Review.

PMID: 16171533


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