Development Scientist – Assay Development

Newcells Biotech provides products and services to the pharmaceutical and biotechnology industry based on induced pluripotent stem cell (iPSC) technology and primary cells. We focus on in vitro cell based assays for pre-clinical toxicity, efficacy and DMPK assessment.

We have an opportunity for a scientist to join one of our teams working on the development of a novel assay for assessing the safety on new therapeutic compounds. The assay involves the use of iPSCs to develop in vitro human organoids for use in high-content screening.

As a member of the Newcell’s team you will be involved in developing this exciting science and technology area working in collaboration with academic teams at Newcastle University.

We are looking for an experienced scientist with a track-record in developing in vitro cell based assays for toxicity and disease modelling to industry standards.

The job is located at our laboratory based at the International Centre for Life in the vibrant city of Newcastle upon Tyne.

We offer a competitive salary for the best candidates of £30,000+ per annum.

 

Key Activities and Responsibilities

  • Developing the assay read-out platform of a high content assay using iPSC derived organoids
  • Validating the assay against known compounds and assessing toxicity response
  • Investigating and developing a novel biomarker approach to assessing in vitro toxicological responses

 

Person Specification

Knowledge and qualifications

Essential
  • Honours Degree in Biological Sciences or equivalent subject
  • Completion of PhD studies or 2+years industry
  • Experience in IT and statistical analysis
Desirable
  • Industry experience of working in a similar area of cell based in vitro assay development

 

Skills

Essential
  • Excellent team working skills
  • Good verbal and written communication skills
  • Diligence and attention to detail
  • Willingness to take responsibility for work streams and follow them through to completion
Desirable
  • Mature, co-operative and flexible approach
  • Ability to adapt to changes in research priorities

 

Practical Experience

Essential
  • Experience with PCR from genomic DNA, cell culture, transfection, gene reporter assays, histology, immunohistochemistry
  • Experience of mammalian cell tissue culture techniques
  • Experience with using PCR for real time quantification of gene expression
  • In vitro cell based assay use and development
Desirable
  • Experience of pluripotent stem cell culture and differentiation techniques
  • Experience in analysis of cells using flow cytometry
  • Experience in confocal microscopy
  • Experience with Western blotting
  • Experience of in vitro toxicology

 

Application Process

To apply for this position please send an email including current CV and a covering statement summarising your interest and suitability for this position to recruitment@newcellsbiotech.co.uk. Please title your email “Application for post of Development Scientist – April 2018”.

Closing date for applications is 5pm London GMT on Friday 25th May 2018. Newcells Biotech reserves the right to change the closing date without notice.