aProximate™ – Recapitulating the human proximal tubule physiology and function

How can we use the aProximate Model?

Identification of transporter-mediated renal drug clearance pathways for xenobiotics during drug development

Identification of transporter-mediated renal drug clearance pathways for xenobiotics during drug development

Identification of cross species differences in renal drug handling – de risking adverse outcomes at first in man

Application of renal model to identify renal target and target engagement/efficacy

Development of screening regime for biologics transport and toxicity

Identification of drug induced kidney damage using clinically relevant biomarkers of nephrotoxicity cross species as a predictive tool to improve ‘first in man’ outcomes.

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aProximate™ - In vitro models for chronic kidney disease (CKD)
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In vitro models for chronic kidney disease (CKD)

Chronic kidney disease (CKD) is a leading public health problem. It is understood to affect 13.4% of the world’s population, and the number of patients with end-stage kidney disease (ESKD) needing renal