Liver Sinusoidal Model - Newcells

Retinal platform

An in vitro, light responsive, retinal model for accurate predictions of in vivo outcomes you can have confidence in.

aProximateTM

Kidney platform

The most advanced near-physiological high throughput kidney proximal tubule cells (PTC) model to investigate drug transport modalities in vitro.

Lung epithelia model

Lung model

A model to investigate airway physiology, viral infection, drug safety and environmental impacts on lung airway epithelia.

Sinusoid iPSC-derived Liver model

Liver model

We are developing a model of liver sinusoid derived from human induced pluripotent stem cells (iPSC).

Liver Sinusoidal Model

Modelling the liver sinusoid

The liver sinusoid is one of the main functional units of liver composed of specialised cells organised to form blood vessels that make up the microcirculation of the liver. There are about one billion sinusoids in human liver. An effective tool to study this critical functional unit is vital and as such Newcells are developing a liver sinusoidal model derived from human induced pluripotent stem cells (iPSC) to meet this need.

Developing a liver sinusoidal model

In 2019, Newcells was awarded a contract under the NC3R Challenge programme to develop a model of the liver sinusoid suitable for batch testing the safety of Yellow Fever vaccine.

Using iPSCs we are developing a membrane supported liver sinusoidal model containing fenestrated endothelium, Kupffer and stellate cells, and hepatocytes. Our programme is confirming the functionality of the model and demonstrating the ability to support viral infection and viremia.

Further work will look at the ability of the model to support other viral infections, as an accurate assay for hepatotoxicity and disease modelling.

Liver sinusoidal model

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