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Modelling the liver sinusoid
The liver sinusoid is one of the main functional units of liver composed of specialised cells organised to form blood vessels that make up the microcirculation of the liver. There are about one billion sinusoids in human liver. An effective tool to study this critical functional unit is vital and as such Newcells are developing a liver sinusoidal model derived from human induced pluripotent stem cells (iPSC) to meet this need.
Developing a liver sinusoidal model
In 2019, Newcells was awarded a contract under the NC3R Challenge programme to develop a model of the liver sinusoid suitable for batch testing the safety of Yellow Fever vaccine.
Using iPSCs we are developing a membrane supported liver sinusoidal model containing fenestrated endothelium, Kupffer and stellate cells, and hepatocytes. Our programme is confirming the functionality of the model and demonstrating the ability to support viral infection and viremia.
Further work will look at the ability of the model to support other viral infections, as an accurate assay for hepatotoxicity and disease modelling.
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