Lung Epithelia Model

A model to investigate airway physiology, viral infection, drug safety, and environmental impacts on lung airway epithelia.

Model viral infection

As demonstrated during the Covid-19 pandemic, understanding viral biology and pathogenicity is crucial for the development of anti-viral therapies. A popular alternative to complex and low-throughput animal models, airway epithelial in vitro models allow the comprehensive study of lung based virology.

The SARS-CoV-2 virus binds to and is internalised via the angiotensin converting enzyme 2 (ACE2) expressed in Newcells Biotech’s 3D in vitro lung model, making it an effective model for studying SARS-CoV-2 infection and replication.

Safety screening in drug development

Due to the large surface area of the lungs, they are highly susceptible to toxicity. In vitro models with limited cell types and functionality are not an effective way to model and measure drug safety. Safety studies exposing animals to high-dose concentrations and tracking toxic responses often don’t effectively replicate reactions in humans.

Newcells Biotech’s iPSC-derived lung model can be used to minimise off-target drug effects with novel approaches to safety screening.

Toxicology testing of environmental pollutants

Current assessments of the impacts of air pollutants on human health are based on epidemiological studies, animal models and immortalised cell lines. However, since cell lines and animal models can poorly represent human physiology, and epidemiological studies alone are rarely able to prove the effects of air pollutants of human health, human in vitro lung models are vital in understanding environmental effects of inhaled toxins.

Newcells Biotech’s lung 3D in vitro model has been tested for inhalation toxicology with cigarette smoke condensate, cerium nanoparticles, busulfan and other environmental xenobiotics.

Newcells Biotech Lung Epithelia Model

Accelerate your research with a reliable and consistent model of lung epithelia.