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Our latest paper in collaboration with Pfizer on the role of OCT2/MATE in creatinine clearance is accepted in JPET.

Illustration of a kidney

MPS Flow Models

Newcells is releasing a new highly engineered MPS flow system fully compatible with all our in vitro cell-based models.

Newcells has launched a new engineered micro-physiological system (MPS) flow technology compatible with our in vitro cell-based models.

The technology was developed using fluid dynamics software and 3-D printing technology to enable physiological flow to be applied to kidney proximal cells in 96-well format. This elegant system uses a unique design of a plate holder precision engineered to work with Transwells®. The design means that cell layers can be subjected to flow without the need for specialised infrastructure and can be quickly adapted to any cell type that has been optimised for growth on Transwells®.

Studying in vitro complex models under flow without the need of specialised equipment

The MPS flow plates have been developed to fit 6, 24 and standard 96-well Transwell® inserts. The design creates two distinct compartments with one compartment subjecting a polarised cell model to flow.  Any analytical readouts developed for well plates can be translated to work on this flow system. One key advantage is that the system allows a large quantity of cells to be subjected flow with benefits to sensitivity and range of assay outputs. The cells are seeded on the basal side of each Transwell®, and are subject to flow and shear forces between 0.1-2 dynes/cm2, generated by slow and constant movement obtained by placing the plates on a rocking device; without the need for complex equipment, pumps, and tubing.

Innovation by design

Using computational fluid dynamics modelling, we have determined the optimal shape and dimensions of the flow channel to obtain constant flow and maximal uniform shear stress exposure across the cell layers. We have researched different materials to select a non-absorptive PDMS-free material to minimise binding of non-specific small molecules, improving the sensitivity and quality of the data produced from the system. The MPS Flow plate is designed to enable us to process a large number of data points rapidly when used with 96-well Transwell® filters

It is now easier than ever to access MPS Flow technology without the need to invest in specialised equipment.

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High throughput


Computational fluid dynamics modelling

Rapid results


Enhancing our cell-based models with a unique flow system

Models available
  • Proximal tubule cell model aProximate™
  • 96-well Transwells®
Measurable outputs
  • FDA recommended biomarkers
  • Cell viability
  • Renal toxicity evaluation
  • Disease modelling
  • Human

Our MPS Flow models

aProximate™ MPS Flow

aProximate™ MPS Flow utilises freshly isolated primary proximal tubule cells from kidney tissue and subjecting them to fluidic media flow and shear stress, increasing sensitivity to the system.

Find out more
Kidney proximal tubule cells immunostained with ZO-1 following exposure to MPS flow

Benefits of our MPS Flow models


Quick and cost-effective access to MPS Flow model technology


High throughput and short time to results


Greater sensitivity as a result of increased expression of key renal transporters

Working with us

Timely service

We rapidly deliver robust data sets to you which are simple and interpretable but sufficiently detailed to answer your questions and meet your important and demanding timelines

Model validation

Our MPS Flow models are rigorously validated to ensure the generation of robust and comparative data predictive of in vivo physiology. Our clients also value our scientific expertise supporting the experimental design as well as the analysis and interpretation of data.

How we support our clients

By providing predictive data, we give our clients confidence in their key decision processes. Our service enables identification of cross-species differences in renal drug handling, identification of clinically relevant transporter-mediated Drug-Drug interactions and assessment of drug-induced kidney damage.

Our expertise

We provide all of the MPS Flow technology expertise required to design, run and analyse each study so that you don’t have to invest time and money into specialised equipment. Our scientific experts have designed and completed hundreds of studies on novel compounds using the unique renal models and provided interpreted data sets to customers to advance candidates into the clinic. Working under a QMS environment, the data and reports have been used to support regulatory submissions.

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