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Announcement:

Our latest paper in collaboration with Pfizer on the role of OCT2/MATE in creatinine clearance is accepted in JPET.

A predictive in vitro primary proximal tubule platform for de-risking of antibiotic induced

Published

9th February, 2024

Published by

Colin Brown et al.

Reference:

Nephrotoxicity is a major reason for drugs failing during clinical development.

Currently there is no in vitro platform that enables cross-species comparisons of drug transport or nephrotoxicity.

Our innovative solution is to develop highly differentiated assay platforms using primary renal proximal tubule cells (PTCs) derived from key animal species to measure both drug transport and drug induced kidney injury a range of biomarkers across species.

Here we showcase data from our highly differentiated Human proximal tubule model

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