Our latest paper in collaboration with Pfizer on the role of OCT2/MATE in creatinine clearance is accepted in JPET.
Presented at the CKD Summit 2023
Drug-induced damage to the kidneys is a key contributor to the development of multiple kidney pathologies, including chronic kidney disease (CKD) which is characterised by the progressive loss of kidney function. A main mechanism of drug-induced toxicity is through damage to kidney cells known as podocytes. Podocytes are specialised epithelial cells that form cytoplasmic projections called foot processes which interdigitate to form a sieve-like barrier for the size-selective filtration of blood. Due to continuous contact with the bloodstream, podocytes are especially susceptible to drug toxicity via prolonged exposure to xenobiotics, and this damage can lead to impaired barrier integrity, causing issues such as proteinuria.
14th March, 2023
Kate Gilroy, Jonathan Lowe, Jessica Ogden, Cindy Carr, Colin Brown, and Kathryn Garner
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