Prof. Lyle Armstrong
Covid-19 is known to infect the lungs. However, the dynamics of viral infection and replication are poorly understood. Alongside the Liverpool School of Tropical Medicine, Newcells Biotech have worked to develop a structurally representative human lung epithelium model of SARS-CoV-2 infection and replication. In this webinar, Professor Lyle Armstrong will present the data that has shown the model can be successfully infected with SARS-CoV-2, via angiotensin converting enzyme 2 (ACE2) proteins expressed on the cell surface and supports replication of the virus once inside its cells. Professor Armstrong will also discuss how the model can be used as a platform to study SARS-CoV-2 pathogenesis and evaluate candidate vaccines and therapeutics.
Dr Piyush Bajaj and Dr Colin Brown
Drug-induced kidney injury (DIKI) is a common reason for compound attrition in drug development pipelines with proximal tubule epithelial cells (PTECs) most commonly associated with DIKI. We explore the potential application of freshly isolated primary hPTECs and translational biomarkers in the assessment of tubular toxicity within the drug discovery pipeline. Colin and Piyush will discuss how measuring biomarkers within a PTEC model can be used to predict tubular toxicity.
Dr Colin Brown
Predictive in vitro primary proximal tubule models for understanding nephrotoxicity in drug development programs
Dr Colin Brown explores how the properties of in vitro proximal tubule epithelial cell (PTEC) models can be used to understand the renal handling of drug molecules and de-risk adverse reactions in drug development programs:
The use of aProximate™ PTEC human and animal models with small molecules and biologics
The value of measuring biomarkers of toxicity
Providing mechanistic and species-specific data about the transport of molecules and predicting potential nephrotoxicity of new drug molecules