Assay-Ready Plates aProximate™

• Drug transporter interactions
• Safety/efficacy studies 
• Drug-drug interactions
• Nephrotoxicity assays
• Disease modelling

1. Reliable and Accurate Results: With the use of  primary human proximal tubule cells, our assay-ready plates offer trustworthy results, aiding in the assessment of drug transport, metabolism, and toxicity. This reliability supports the identification of promising drug candidates and minimises potential risks.
2. A Realistic In Vitro Model: Emulate human physiology more realistically with our assay-ready plates, offering insights that align more closely with clinical outcomes and mechanistic understanding of renal drug handling.  The aProximate™ model facilitates more precise predictions of drug behaviour and effects due to higher expression of renal transporters compared to other models.
3. Versatile Applications: aProximate™ Assay-Ready Plates support various applications, including drug transporter studies, ADME/DMPK evaluations, and toxicity and safety screenings. This versatility streamlines experimental processes and optimises resource utilisation.
4. Expert Assistance: Our team of experts is committed to your success. We offer technical support and guidance to ensure that you obtain meaningful results with our assay-ready plates.

Designed with your convenience in mind, our aProximate™ Assay-Ready Plates are ready to go and enable you to focus on your research without the hassle of extensive cell culture procedures.

We ship the primary proximal tubule cells in stasis media, a gel that preserves the cells’ viability during transit. These cells are maintained at a stable 4^oC to ensure their optimal condition upon arrival. Our streamlined delivery process ensures the cells’ integrity, and we take pride in providing high-quality products that meet your research needs.

Once the Assay-Ready Plates are in your hands, a simple and user-friendly protocol guides you through the process of removing the stasis gel and replacing it with the supplied maintenance media. This step-by-step guide ensures a smooth transition of recovery for the proximal tubule cells, allowing you to establish a functional and polarized cell monolayer with ease. All proximal tubule cells included in our assay-ready plates undergo rigorous quality control testing for your peace of mind.

TEER measurements indicate when the cells have formed a confluent monolayer, signalling their readiness for experimentation. Thus a TEER (Trans-epithelial Electrical Resistance) meter is required to determine the optimal time for assay. Our user guide provides comprehensive details on using the TEER meter effectively to assess the monolayer’s confluency.

aProximate™ is available for shipment to customers to perform kidney transporter and toxicity studies in-house. aProximate™ Assay-Ready plates are provided in either 24-well or 96-well Transwell® format.

• Human aProximate™ proximal tubule cells
• Format : 24- or 96-well Transwell®
• Shipped in stasis media (gel)
• Fully validated shippment at 4^oC
• Require immediate attention and revival immediately upon receipt

eBook available

Read the renal proximal tubule cells platform eBook for more insights

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