A recent study by a team at Unilever has demonstrated the predictive power of NAM approaches for the comprehensive safety assessment of compounds by combining in vitro models with advanced computational techniques. They used the aProximate™ proximal tubule cell model to assess potential nephrotoxicity and renal transport kinetics.
Sumathy Mathialagan, Git Chung, Keith Pye, A. David Rodrigues, Manthena V. S. Varma and Colin Brown
Find out moreAlex Gledhill, Rachael Bowen, Michael Bartels, Andrew Bond, Git Chung, Colin D. A. Brown, Keith Pye & Tarang Vora
Find out moreColin D. A. Brown. Drug Metabolism and Pharmacokinetics. 2017; 32(1): S14-S15
Find out moreThe aProximateTM model for renal drug safety/efficacy and transporter studies
Development of photoreceptor outer segments in human iPSC derived retinal organoids produced at large scale
Developing predictive in vitro Glomerulus , Proximal Tubule and Loop of Henle renal cell model platforms to investigate the renal uptake and nephrotoxic liability of large molecules
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