Announcement:

Our latest paper in collaboration with Pfizer on the role of OCT2/MATE in creatinine clearance is accepted in JPET.

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Resources

Articles and Posters

A Sensitive Nephrotoxicity Assay of in vitro Podocyte Effacement

Kathryn Garner, Ben Coker, Nick Brittain, Kirsten Ramsey, Kate Gilroy, Elena Tasinato

Significance of organic anion transporter 2 and organic cation transporter 2 in creatinine clearance: Mechanistic evaluation using freshly-prepared human primary renal proximal tubule cells

Sumathy Mathialagan, Git Chung, Keith Pye, A. David Rodrigues, Manthena V. S. Varma and Colin Brown

A Live Cell High Content Imaging Assay for Monitoring Large Molecules Uptake into aProximateTM Proximal Tubule Epithelial Cells via Megalin and Cubulin

Jonathon Lowe, Ben Coker, Keith Pye, Colin D.A. Brown, Kathryn Garner

Scientific eBooks and Protocols

aProximate™ Assay-Ready Plates User Guide Cover.

aProximate™ Assay-Ready Plates (Human, 96-well) User Guide

The front cover of the aProximate ebook

aProximate™ eBook

Transporter and drug-drug interaction studies

aProximate™ Transporter & drug-drug interaction studies

Q&A with our scientists

The inside story of the development of Newcells’ MPS flow model: Scientific chat with Dr Colin Brown

Videos and Webinars

Newcells Biotech

Retinal Model Capabilities

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Meet Dr Valeria Chichagova – Our Associate Director of iPSC technology and Head of Retina

Dr Colin Brown

The Kidney as a Therapeutic Target: Targeting Therapeutics to the Proximal Tubule

Case Studies

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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A microscope image of a nephron model