Resources
Scientific Publications
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Comparison of the Impact of VRP-034 and Polymyxin B upon markers of Kidney Injury in Human Proximal Tubule Monolayers In Vitro
Keith Pye, Elena Tasinato, Siannah Shuttleworth, Claire Devlin and Colin Brown
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Development of a Highly Differentiated Human Primary Proximal Tubule MPS Model (aProximate MPS Flow)
Francesca Pisapia, Donovan O'Brien, Elena Tasinato, Kathryn L. Garner and Colin D.A. Brown
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Significance of OAT2 and OCT2 in creatinine clearance: Mechanistic evaluation using freshly-prepared human primary renal proximal tubule cells
Sumathy Mathialagan, Git Chung, Keith Pye, A. David Rodrigues, Manthena V. S. Varma and Colin Brown
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The aProximateTM model for renal drug safety/efficacy and transporter studies
Developing predictive in vitro Glomerulus , Proximal Tubule and Loop of Henle renal cell model platforms to investigate the renal uptake and nephrotoxic liability of large molecules
An in vitro model that predicts Antibiotic Renal Toxicity
Case Studies
View allSafety and efficacy evaluation of a novel therapeutic AAV vectors using a human retinal organoid model
Evaluation of a novel therapeutic AAV vectors
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Comparing the transduction efficiency of two AAV vectors in RPE and Retinal Organoid models derived from iPSCs lines
Comparing the transduction efficiency of two AAV vectors
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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
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In vitro evaluation of ocular toxicity and phenotypic rescue
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In vitro selection of the most relevant species to predict human
Evaluation of glomerular ADC toxicity in podocytes
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Gene therapy viral vector assessment on retinal organoids
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Gene therapy viral vector assessment on RPE cells
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Predicting human renal injury from antisense oligonucleotide (ASO)
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