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Safety and efficacy evaluation of a novel therapeutic AAV vectors using a human retinal organoid model

Evaluation of a novel therapeutic AAV vectors

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Comparing the transduction efficiency of two AAV vectors in RPE and Retinal Organoid models derived from iPSCs lines

Comparing the transduction efficiency of two AAV vectors

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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Evaluation of glomerular ADC toxicity in podocytes

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Isolated primary podocytes immunostained for cilia

Gene therapy viral vector assessment on retinal organoids

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Gene therapy viral vector assessment on RPE cells

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RPE

Predicting human renal injury from antisense oligonucleotide (ASO)

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