Resources
Scientific Publications
View all
Comparison of the Impact of VRP-034 and Polymyxin B upon markers of Kidney Injury in Human Proximal Tubule Monolayers In Vitro
Keith Pye, Elena Tasinato, Siannah Shuttleworth, Claire Devlin and Colin Brown
Find out more
Development of a Highly Differentiated Human Primary Proximal Tubule MPS Model (aProximate MPS Flow)
Francesca Pisapia, Donovan O'Brien, Elena Tasinato, Kathryn L. Garner and Colin D.A. Brown
Find out more
Significance of OAT2 and OCT2 in creatinine clearance: Mechanistic evaluation using freshly-prepared human primary renal proximal tubule cells
Sumathy Mathialagan, Git Chung, Keith Pye, A. David Rodrigues, Manthena V. S. Varma and Colin Brown
Find out morePosters
View all
The aProximateTM model for renal drug safety/efficacy and transporter studies
Developing predictive in vitro Glomerulus , Proximal Tubule and Loop of Henle renal cell model platforms to investigate the renal uptake and nephrotoxic liability of large molecules
An in vitro model that predicts Antibiotic Renal Toxicity
Case Studies
View allAnalysis of the effect of a compound on retinal microtissue composition
Find out more
Development of a human in vitro model for retinitis pigmentosa
Find out more
Assessing the validity of a nephron model for a metabolic disease study
Find out more
DDI study on renal creatinine clearance mechanism
Find out more
Predicting renal retention of radioconjugates in a human relevant in vitro model
Find out more
Safety and efficacy evaluation of a novel therapeutic AAV vectors using a human retinal organoid model
Find out more
Comparing the transduction efficiency of two AAV vectors in RPE and Retinal Organoid models derived from iPSCs lines
Find out more
Comprehensive toxicity study on retinal ganglion cells in early-stage human retinal organoids
Find out more
Development and characterisation of an early-stage retinal organoid disease model (for non-ocular disease)
Find out more
Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
Find out more
Comprehensive in vitro evaluation of ocular toxicity and phenotypic rescue
Find out more
In vitro selection of the most relevant species to predict human
Evaluation of glomerular ADC toxicity in podocytes
Find out more
Gene therapy viral vector assessment on retinal organoids
Find out more
Gene therapy viral vector assessment on RPE cells
Find out more
Predicting human renal injury from antisense oligonucleotide (ASO)
Find out more
