Announcement:

New scientific publication in collaboration with the University of Newcastle on modelling Stargardt disease (STGD1) in vitro with retinal organoids (RO) to unravel genotype-phenotype correlations

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Resources

Scientific Publications

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Comparison of the Impact of VRP-034 and Polymyxin B upon markers of Kidney Injury in Human Proximal Tubule Monolayers In Vitro

Keith Pye, Elena Tasinato, Siannah Shuttleworth, Claire Devlin and Colin Brown

Development of a Highly Differentiated Human Primary Proximal Tubule MPS Model (aProximate MPS Flow)

Francesca Pisapia, Donovan O'Brien, Elena Tasinato, Kathryn L. Garner and Colin D.A. Brown

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Significance of OAT2 and OCT2 in creatinine clearance: Mechanistic evaluation using freshly-prepared human primary renal proximal tubule cells

Sumathy Mathialagan, Git Chung, Keith Pye, A. David Rodrigues, Manthena V. S. Varma and Colin Brown

Posters

The aProximateTM model for renal drug safety/efficacy and transporter studies

Developing predictive in vitro Glomerulus , Proximal Tubule and Loop of Henle renal cell model platforms to investigate the renal uptake and nephrotoxic liability of large molecules

An in vitro model that predicts Antibiotic Renal Toxicity

Fact Sheets

The aProximateᵀᴹ Proximal tubule cells (PTC) model

Press releases

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Newcells Biotech

Newcells Biotech strengthens executive and US team with key appointments

Scientific eBooks and Protocols

aProximate™ Assay-Ready Plates User Guide Cover.

aProximate™ Assay-Ready Plates (Human, 96-well) User Guide

The front cover of the aproximate assay ready plates ebook

aProximate™ Assay-Ready Plates (Human, 24-well) User Guide

The front cover of the aProximate ebook

Renal Proximal Tubule Cells Model eBook

Q&A with our scientists

Dr Colin Brown face inside cells

The inside story of the development of Newcells’ MPS flow model: Scientific chat with Dr Colin Brown

Videos and Webinars

Newcells Biotech – Kidney Model Capabilities

Dr Mike Nicholds – How Newcells works with Clients

Dr Mike Nicholds – Newcells Offerings

Case Studies

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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Evaluation of glomerular ADC toxicity in podocytes

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Isolated primary podocytes immunostained for cilia

Gene therapy viral vector assessment on retinal organoids

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Gene therapy viral vector assessment on RPE cells

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RPE

Predicting human renal injury from antisense oligonucleotide (ASO)

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