Announcement:

Our latest paper in collaboration with Pfizer on the role of OCT2/MATE in creatinine clearance is accepted in JPET.

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Resources

Articles and Posters

Significance of organic anion transporter 2 and organic cation transporter 2 in creatinine clearance: Mechanistic evaluation using freshly-prepared human primary renal proximal tubule cells

Sumathy Mathialagan, Git Chung, Keith Pye, A. David Rodrigues, Manthena V. S. Varma and Colin Brown

A Live Cell High Content Imaging Assay for Monitoring Large Molecules Uptake into aProximateTM Proximal Tubule Epithelial Cells via Megalin and Cubulin

Jonathon Lowe, Ben Coker, Keith Pye, Colin D.A. Brown, Kathryn Garner

Development of highly-differentiated human primary proximal tubule MPS model (aProximate MPS™ Flow)

Francesca Pisapia, Elena Tasinato, Kathryn Garner, and Colin Brown

Scientific eBooks and Protocols

aProximate™ Assay-Ready Plates User Guide Cover.

aProximate™ Assay-Ready Plates (Human, 96-well) User Guide

The front cover of the aproximate assay ready plates ebook

aProximate™ Assay-Ready Plates (Human, 24-well) User Guide

The front cover of the aProximate ebook

aProximate™ eBook

Q&A with our scientists

The inside story of the development of Newcells’ MPS flow model: Scientific chat with Dr Colin Brown

Videos and Webinars

Newcells Biotech

MPS Flow video

Dr Colin Brown

The Kidney as a Therapeutic Target: Targeting Therapeutics to the Proximal Tubule

Reducing compound attrition by predicting renal tubular toxicity with in vitro PTEC models

Reducing compound attrition by predicting renal tubular toxicity with in vitro PTEC models

Case Studies

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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A microscope image of a nephron model