Announcement:

New scientific publication in collaboration with the University of Newcastle on modelling Stargardt disease (STGD1) in vitro with retinal organoids (RO) to unravel genotype-phenotype correlations

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Resources

Scientific Publications

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Significance of OAT2 and OCT2 in creatinine clearance: Mechanistic evaluation using freshly-prepared human primary renal proximal tubule cells

Sumathy Mathialagan, Git Chung, Keith Pye, A. David Rodrigues, Manthena V. S. Varma and Colin Brown

water being sprayed on grass.

The chlorophenoxy herbicide MCPA: A mechanistic basis for the observed differences in toxicological profile in humans & rats vs dogs.

Alex Gledhill, Rachael Bowen, Michael Bartels, Andrew Bond, Git Chung, Colin D. A. Brown, Keith Pye & Tarang Vora

Newcells Biotech

Primary human proximal tubule cell monolayers as a predictive model of renal phosphate homeostasis in heath & disease

Colin D. A. Brown. Drug Metabolism and Pharmacokinetics. 2017; 32(1): S14-S15

Posters

The aProximateTM model for renal drug safety/efficacy and transporter studies

An in vitro Human Primary Thick Ascending Limb Model For The Assessment of Compound Nephrotoxicity

A Live Cell High Content Imaging Assay for Monitoring Large Molecules Uptake into aProximateTM Proximal Tubule Epithelial Cells via Megalin and Cubulin

Fact Sheets

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Press releases

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Scientific eBooks and Protocols

aProximate™ Assay-Ready Plates User Guide Cover.

aProximate™ Assay-Ready Plates (Human, 96-well) User Guide

The front cover of the aproximate assay ready plates ebook

aProximate™ Assay-Ready Plates (Human, 24-well) User Guide

The front cover of the aProximate ebook

Renal Proximal Tubule Cells Model eBook

Q&A with our scientists

Dr Colin Brown face inside cells

The inside story of the development of Newcells’ MPS flow model: Scientific chat with Dr Colin Brown

Videos and Webinars

Newcells Biotech – Kidney Model Capabilities

Dr Mike Nicholds – How Newcells works with Clients

Dr Mike Nicholds – Newcells Offerings

Case Studies

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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Evaluation of glomerular ADC toxicity in podocytes

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Isolated primary podocytes immunostained for cilia

Gene therapy viral vector assessment on retinal organoids

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Gene therapy viral vector assessment on RPE cells

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RPE

Predicting human renal injury from antisense oligonucleotide (ASO)

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