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Scientific Publications

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Unravelling genotype-phenotype correlations in Stargardt disease using patient-derived retinal organoids

Incorporating microglia-like cells in human induced pluripotent stem cell-derived retinal organoids

Incorporating microglia-like cells in human induced pluripotent stem cell-derived retinal organoids

Valeria Chichagova, Maria Georgiou, Madeleine Carter, Birthe Dorgau, Gerrit Hilgen, Joseph Collin, Rachel Queen, Git Chung, Jila Ajeian, Marina Moya-Molina, Stefan Kustermann, Francois Pognan, Philip Hewitt, Michael Schmitt, Evelyne Sernagor, Lyle Armstrong, Majlinda Lako

Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids

Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids

Michelle E. McClements, Hannah Steward, William Atkin, Emily Archer Goode, Carolina Gándara, Valeria Chichagova, and Robert E. MacLaren

Posters

Generation of a physiologically relevant in vitro model of autosomal dominant Retinitis Pigmentosa caused by RHO-P23H mutation using 3D retinal organoids

Development of photoreceptor outer segments in human iPSC derived retinal organoids produced at large scale

Comparison of multiple batches of human iPSC-derived retinal organoids produced at large scale

White Papers

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Fact Sheets

iPSC-derived Retinal Pigment Epithelium (RPE)

iPSC-derived Retinal Organoids (RO)

Scientific eBooks and Protocols

The front cover of the retinal organoid ebook

Retinal Organoids eBook

Q&A with our scientists

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Q&A with Dr Carolina Gandara, Head of retina assay development

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Latest trends in Retinal Organoids: Scientific chat with Dr Valeria Chichagova

Videos and Webinars

In Vitro Retinal Models: A New Era in Drug Discovery & Gene Therapy

How Newcells Works With Clients – Dr Mike Nicholds

The Newcells Biotech Offering – Dr Mike Nicholds

Case Studies

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Analysis of the effect of a compound on retinal microtissue composition

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Development of a human in vitro model for retinitis pigmentosa

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Assessing the validity of a nephron model for a metabolic disease study

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DDI study on renal creatinine clearance mechanism

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Predicting renal retention of radioconjugates in a human relevant in vitro model

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Safety and efficacy evaluation of a novel therapeutic AAV vectors using a human retinal organoid model

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Comparing the transduction efficiency of two AAV vectors in RPE and Retinal Organoid models derived from iPSC lines

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GFP immunofluorescence and brightfield images of RPE

Comprehensive toxicity study on retinal ganglion cells in early-stage human retinal organoids

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Development and characterisation of an early-stage retinal organoid disease model (for non-ocular disease)

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

Comprehensive in vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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Evaluation of glomerular ADC toxicity in podocytes

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Isolated primary podocytes immunostained for cilia

Gene therapy viral vector assessment on retinal organoids

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Gene therapy viral vector assessment on RPE cells

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RPE

Predicting human renal injury from antisense oligonucleotide (ASO)

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