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The aProximate™ in vitro renal proximal tubule cell model as a platform to investigate the renal uptake and nephrotoxic liability of Antisense Oligonucleotide drug molecules
Colin D A Brown, Siannah Shuttleworth, Kathryn Garner, Jonathan Lowe, Keith Pye
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The aProximate™ in vitro renal proximal tubule cell model as a platform to investigate the renal uptake & nephrotoxic liability of Antisense Oligonucleotide drug molecules
Colin D A Brown, Siannah Shuttleworth, Jonathan Lowe, Keith Pye
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The chlorophenoxy herbicide MCPA: A mechanistic basis for the observed differences in toxicological profile in humans & rats vs dogs.
Alex Gledhill, Rachael Bowen, Michael Bartels, Andrew Bond, Git Chung, Colin D. A. Brown, Keith Pye & Tarang Vora
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Case Studies
View allQuantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
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In vitro evaluation of ocular toxicity and phenotypic rescue
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In vitro selection of the most relevant species to predict human renal toxicity
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