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Latest Publication: Read our teams’ latest paper in Antibiotics, showing reduced nephrotoxicity of a novel formulation of polymyxin B compared to the clinical formulation using a validated primary human proximal tubule cell model.

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Resources: Scientific publications

Comparison of the Impact of VRP-034 and Polymyxin B upon markers of Kidney Injury in Human Proximal Tubule Monolayers In Vitro

Keith Pye, Elena Tasinato, Siannah Shuttleworth, Claire Devlin and Colin Brown

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Newcells Biotech

Development of a Highly Differentiated Human Primary Proximal Tubule MPS Model (aProximate MPS Flow)

Francesca Pisapia, Donovan O'Brien, Elena Tasinato, Kathryn L. Garner and Colin D.A. Brown

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Significance of OAT2 and OCT2 in creatinine clearance: Mechanistic evaluation using freshly-prepared human primary renal proximal tubule cells

Sumathy Mathialagan, Git Chung, Keith Pye, A. David Rodrigues, Manthena V. S. Varma and Colin Brown

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Incorporating microglia-like cells in human induced pluripotent stem cell-derived retinal organoids

Incorporating microglia-like cells in human induced pluripotent stem cell-derived retinal organoids

Valeria Chichagova, Maria Georgiou, Madeleine Carter, Birthe Dorgau, Gerrit Hilgen, Joseph Collin, Rachel Queen, Git Chung, Jila Ajeian, Marina Moya-Molina, Stefan Kustermann, Francois Pognan, Philip Hewitt, Michael Schmitt, Evelyne Sernagor, Lyle Armstrong, Majlinda Lako

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water being sprayed on grass.

The chlorophenoxy herbicide MCPA: A mechanistic basis for the observed differences in toxicological profile in humans & rats vs dogs.

Alex Gledhill, Rachael Bowen, Michael Bartels, Andrew Bond, Git Chung, Colin D. A. Brown, Keith Pye & Tarang Vora

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Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids

Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids

Michelle E. McClements, Hannah Steward, William Atkin, Emily Archer Goode, Carolina Gándara, Valeria Chichagova, and Robert E. MacLaren

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Newcells Biotech

Primary human proximal tubule cell monolayers as a predictive model of renal phosphate homeostasis in heath & disease

Colin D. A. Brown. Drug Metabolism and Pharmacokinetics. 2017; 32(1): S14-S15

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Newcells Biotech

Review of pharmacokinetics & metabolism of triclopyr herbicide in mammals: Impact on safety assessments

Michael Bartels, Colin Brown, Git Chung, Melissa Chan, Claire Terry, Sean Gehen, Marco Corvaro Regulatory toxicology and pharmacology. 2020; 116:104714

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Newcells Biotech

Human primary proximal tubule cell monolayers as a novel predictive model of nephrotoxicity

Git Chung, Sarah Billington, R. D. Wilde, Colin Brown Toxicology Letters. 2016;258:S139-S140

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