Announcement:

Our latest paper in collaboration with Pfizer on the role of OCT2/MATE in creatinine clearance is accepted in JPET.

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Resources

Articles and Posters

A Live Cell High Content Imaging Assay for Monitoring Large Molecules Uptake into aProximateTM Proximal Tubule Epithelial Cells via Megalin and Cubulin

Jonathon Lowe, Ben Coker, Keith Pye, Colin D.A. Brown, Kathryn Garner

Development of highly-differentiated human primary proximal tubule MPS model (aProximate MPS™ Flow)

Francesca Pisapia, Elena Tasinato, Kathryn Garner, and Colin Brown

The aProximate™ in vitro renal proximal tubule cell model as a platform to investigate the renal uptake and nephrotoxic liability of Antisense Oligonucleotide drug molecules

Colin D A Brown, Siannah Shuttleworth, Kathryn Garner, Jonathan Lowe, Keith Pye

Scientific eBooks and Protocols

The front cover of the retinal organoid ebook

Retinal Organoids eBook

Q&A with our scientists

Q&A with Dr Carolina Gandara, Head of retina assay development

The inside story of the development of Newcells’ MPS flow model: Scientific chat with Dr Colin Brown

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Latest trends in Retinal Organoids: Scientific chat with Dr Valeria Chichagova

Videos and Webinars

Meet Dr Megan Webster – Our Head Of Lung Development

Newcells Biotech

Retinal Model Capabilities

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Meet Dr Valeria Chichagova – Our Associate Director of iPSC technology and Head of Retina

Case Studies

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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A microscope image of a nephron model