A robust, physiologically relevant air-liquid interface (ALI) lung model of the small airways to enable scientific research and drug discovery
Newcells Biotech’s human small airway epithelial cell (SAEC) air-liquid interface model closely recapitulates the epithelial physiology of the lung. Derived from differentiated small airway basal cells, our SAEC model comprises the main epithelial cell types namely basal, club (Clara), goblet and ciliated cells. With an established epithelial barrier, active mucus production and functional cilia, our air-liquid inferface (ALI) SAEC model is an invaluable tool for drug discovery.
The small airways of the lung are the terminal bronchioles, vital for the conduction of air from the larger airways to the alveolar region for gas exchange. Unlike the larger airways, the small airways are non-cartilaginous, with a diameter < 2 mm, making them a key site of airway resistance. The presence of excessive mucus within the small airways can often lead to airway obstruction such as that observed in chronic obstructive pulmonary disease (COPD), asthma, and other respiratory diseases. Recent studies have also suggested a role of the small airways in the development and progression of lung fibrosis. As the study of the small airways in vivo is limited due to their fragility, size and location, our in vitro human lung small airway epithelial cell model provides a powerful tool for the study of lung physiology, drug toxicity and response to epithelial damage.
We currently offer a range of analytical readouts in line with project requirements, example readouts include;
- TransEpithelial Electrical Resistance (TEER)
- Cytokine release
- Gene expression modifications
- Cell viability & compound toxicity
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