Latest Publication: Read our teams’ latest paper in Antibiotics, showing reduced nephrotoxicity of a novel formulation of polymyxin B compared to the clinical formulation using a validated primary human proximal tubule cell model.
The proximal tubules of the kidney nephron play a key role in the reabsorption of filtered amino acids, glucose, solutes, and low molecular weight proteins, such as albumin, from the tubular filtrate. Many xenobiotics are also reabsorbed here, which if not rapidly cleared from the cells, can cause nephrotoxicity.
20th September, 2023
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