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The results of a recent collaboration between Sanofi, GSK, Lilly, Vesalius Therapeutics, Leiden University, Heidelberg University, ElmorePathology and Newcells aimed at enhancing safety assessments has just been published. Find out how rat kidney gene co-expression networks has enabled biomarker identification and human translation for renal safety assessments.
The proximal tubule (PT) is the key nephron segment mediating renal drug elimination and is the primary site of drug induced nephrotoxicity.
However, current animal studies have proved poorly predictive of human outcome. To address this, there has been a recent upsurge in physiological relevant microphysiological systems (MPS) of PT to recapitulate differentiation and function in vitro. Here we present results from our recently developed aProximate MPS™ human PT platform (Patent No: G001336.GB), in which primary human PT cells are subject to fluidic media flow and a shear stress between 0.1-2 dynes/cm².
19th January, 2023
Donovan O’Brien, Francesca Pisapia, Elena Tasinato, Kathryn Garner and Colin Brown
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