Overcoming technical difficulties of in vitro assay – development

Modeling Fibroblast-to-Myofibroblast Transition (FMT)

TGF-β1 mediated activation of fibroblasts, their transition to α-SMA expressing myofibroblasts, and associated increase in the expression and deposition of extracellular matrix proteins represents one of the underlying pathologic mechanisms of fibrosis.