Advancing Radioconjugate Therapeutics: Leveraging Kidney PTC Models for Predictive Uptake and Toxicity Assessment

Dr Adam Pearson discusses “Advancing Radioconjugate Therapeutics: Leveraging Kidney PTC Models for Predictive Uptake and Toxicity Assessment”.

During the talk, Dr Pearson:

• Examines the use of in vitro kidney proximal tubule cell (PTC) models to assess renal uptake of radioconjugate therapeutics during early-stage development.
• Highlights key advancements in PTC model systems, that better replicate renal physiology and transport mechanisms relevant to radioconjugate exposure.
• Showcases case studies demonstrating how in vitro PTC assays support compound screening and preclinical safety assessment of radioconjugate compounds.

Date: Tuesday 22nd July 2025