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The results of a recent collaboration between Sanofi, GSK, Lilly, Vesalius Therapeutics, Leiden University, Heidelberg University, ElmorePathology and Newcells aimed at enhancing safety assessments has just been published. Find out how rat kidney gene co-expression networks has enabled biomarker identification and human translation for renal safety assessments.
In this webinar, Dr Colin Brown (Chief Scientific Officer at Newcells) gives an overview of the various transporters expressed in the aProximate™ PCT in vitro model. More specifically he discusses phosphate transport, Urate transport, transport of large molecules and oligonucleotides as well as amino-acid transport.
Dr Brown also explain why the model is ideal to understand renal drug handling and drug-drug interactions (DDI) in the kidney and how it can be used to identify renal target engagement and evaluate target efficacy.
Date: Friday 24th September 2021
September 24, 2021
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