Use of the aProximate Proximal Tubule Cell model for the evaluation of safety and renal accumulation of radioconjugates and large molecules

The aProximate^TM Proximal Tubule Cell (PTC) model offers a cutting-edge platform for the evaluation of drug-induced nephrotoxicity, radioconjugate retention, and the accumulation of large molecules (ADCs, ASO, antibiotics, peptides etc) in the proximal tubule.

This white paper outlines the advantages of using the aProximate^TM PTC model in predicting and assessing renal safety in the early stages of drug development, focusing on its application in the context of renal radioconjugates and large molecule dynamics.