In vitro tissue models that mimic in vivo human physiology to improve drug discovery
In vitro tissue models that mimic in vivo human physiology to improve drug discovery
In vitro tissue models that mimic in vivo human physiology to improve drug discovery
Home › Resources › White papers › Use of the aProximate Proximal Tubule Cell model for the evaluation of safety and renal accumulation of radioconjugates and large molecules
The aProximateTM Proximal Tubule Cell (PTC) model offers a cutting-edge platform for the evaluation of drug-induced nephrotoxicity, radioconjugate retention, and the accumulation of large molecules (ADCs, ASO, antibiotics, peptides etc) in the proximal tubule.
This white paper outlines the advantages of using the aProximateTM PTC model in predicting and assessing renal safety in the early stages of drug development, focusing on its application in the context of renal radioconjugates and large molecule dynamics.
2nd May, 2025
Colin Brown
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