A robust, physiologically relevant air-liquid interface (ALI) small airways model comprising all relevant cell types for accurate drug discovery data.
Newcells Biotech’s human small airway epithelial cell (SAEC) model closely recapitulates the epithelial physiology of the lung.
Overview
Derived from small airway basal cells, our SAEC model comprises all the critical epithelial cell types namely basal, club (Clara), goblet and ciliated cells.
With an established epithelial barrier, active mucus production and functional cilia, our air-liquid interface (ALI) SAEC model is an invaluable tool for drug discovery.
Toxicity assay
This assay offers a series of readouts to assess the toxicity of both single and repeat dosing studies. Using internal assay controls, we provide comprehensive data sets to predict the potential toxicity of therapeutics
Efficacy/target engagement assay
This service allows for testing the effect of therapeutic compounds in a physiologically relevant environment. Our comprehensive assay delivers a full data set to characterise target engagement.
Toxicity Assay - Readouts
- TEER
- ATP
- LDH
- MTT
Efficacy/Target Engagement Assay - Readouts
- Gene expression modifications
- Immunocytochemistry
