A suite of models to predict a drugs effect on the nephron
Models available
- Proximal tubule cell model aProximate™
- Glomerulus model
- The Loop of Henle (contact us for more information)
- Proximal tubule cell model aProximate™
- Glomerulus model
- The Loop of Henle (contact us for more information)
Measurable outputs
- Flux measurement
- Net transport measurements
- Measurement of intracellular drug and metabolite concentrations
- Identification of transporter-mediated Drug-Drug interactions
- FDA recommended biomarkers
- Cell viability and monolayer integrity
- Glomerular permeability
- Flux measurement
- Net transport measurements
- Measurement of intracellular drug and metabolite concentrations
- Identification of transporter-mediated Drug-Drug interactions
- FDA recommended biomarkers
- Cell viability and monolayer integrity
- Glomerular permeability
Applications
- Renal toxicity evaluation
- Drug-Drug interactions
- Drug transporter assays
- Disease modelling
- Renal toxicity evaluation
- Drug-Drug interactions
- Drug transporter assays
- Disease modelling
Species
- Human
- Mouse
- Rat
- Dog
- Non-human Primate (NHP)
- Human
- Mouse
- Rat
- Dog
- Non-human Primate (NHP)
Our kidney tissue models
aProximate™
aProximate™ is a validated, near physiological renal transporter model for use in drug transport and renal toxicity studies.
More Information
Glomerulus
A fully differentiated, primary podocyte cell model isolated from fresh kidney tissue for the assessment of drug-induced renal toxicity as well as glomerular permeability.
More Information
Benefits of our models
Express all major renal transporters and other functional properties
Available in versions modelling all pre-clinical species
Extensively validated on DDI and nephrotoxicity test compounds
Services
Drug transporter interactions
Identification of transporter-mediated renal drug clearance pathways using our renal transporter model.
Drug-Drug interactions
Understand potential transporter-mediated drug to drug interactions using our model that expresses all the key transporter families.
Cross species comparison
Identify and explain differences in drug effects between human and all the common pre-clinical species to optimise studies.
Kidney toxicity
High throughput in vitro drug screening for kidney safety and toxicity testing using clinically relevant biomarkers as a predictive tool.
Disease modelling
Our kidney tissue models are ideal tools to model renal diseases such as chronic kidney disease (CKD), gout and metabolic disorders.
Working with us
Timely service
Our ethical and secure primary tissue supply chain enables us to run studies and produce products to meet customers important and demanding timelines. We process multiple primary tissue every month meaning order-to-data response times can fit with the most demanding of customer deadlines.
Model validation
Our kidney tissue models are well-characterised and rigorously validated to ensure the generation of robust and comparable data predictive of in vivo renal physiology. Our clients also value our scientific expertise supporting the experimental design as well as the analysis and interpretation of data.
How we support our clients
By providing predictive data, we give our clients confidence in their key decision processes using our renal transporter models. Our service enables identification of cross-species differences in renal drug handling, identification of clinically relevant transporter-mediated Drug-Drug interactions and assessment of drug-induced kidney damage.
Our expertise
Our team have an in-depth knowledge of kidney physiology, cell-based models and assay development. They have designed and completed hundreds of studies on novel compounds using the unique renal models and provided interpreted data sets to customers to advance candidates into the clinic. Working under a QMS environment, the data and reports have been used to support regulatory submissions.
