Service Selector

Which model are you interested in using?

What are you looking to find out?

The following services can be run individually or as combinations. Select each service individually to define your study.

We suggest customising each assay individually

Is the target transporter of your compound known to you?

What are you looking to examine?

We suggest a 3 phased customised comprehensive study on our aProximate model

1. aProximate Model Transporter PRESENCE Qualification Study

This step consists in quantifying the expression of the transporter of interest in the model by qPCR, immunohistochemistry and Western blot.

2. aProximate Model Transporter FUNCTION Qualification Study

This study aims to validate functionality of the transporter of interest in the model by measuring and inhibiting flux of a prototypic substrate.

What data are you looking to get?

What do you wish to achieve?

What type of model are you looking to use?

We suggest customising each assay individually.

We will carry out a 2 step service

1. Development of your functional disease model

We will develop a robust and validated disease model from which you can then obtain key insights into the basis of the disease and enable the rapid evaluation of new treatments in vitro.

You will need to provide us with the relevant iPSCs line for our team of experts to generate and validate the retinal organoids or RPE models.

The validation includes: brightfield imaging morphological characterisation and qualitative and quantitative analysis of key markers expression by fluorescent imaging and gene expression. Studies on RPE also include analysis of phagocytosis of photoreceptors, trans-epithelial resistance (TEER) measurements, growth factor secretion and protein expression analysis by flow cytometry.

Identify the right service to answer your questions

Kidney

Retina

Effect of your Agent on Nephron Transporters

Uptake/Flux data of your compound

Safety and toxicity of your compound

Something Else

Effect of your compound on Nephron Transporters

Uptake/Flux Data of Your Test Agent

Safety/Toxicity of Your Test Agent

Yes

No

Yes

No

Cellular Injury

Renal Toxicity

Something else

1. aProximate Model Transporter PRESENCE Qualification Study

2. aProximate Model Transporter FUNCTION Qualification Study

3. Compound Functional/Efficay study or Compund Uptake study

Functional data

Intracellular accumulation data only

Gain functional transport data and transporter efficacy information

Obtain data relating to the intracellular accumulation of your compund

Disease Model

Healthy Model

Retinal Safety/Toxicity Data

Efficacy Study

Gene Therapy Vector Assessment

1. Development of your functional disease model

2. Safety, toxicity, efficacy or gene therapy assessment studies.

Retinal Safety and Toxicity Study

Efficacy Study

Gene Therapy Vector Assessment

Something Else

A snapshot of the effect of your compound on cell morphology and viability.

Retinal organoids

RPE

Both

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