The most advanced, near physiological, in vitro kidney proximal tubule cell (PTC) model.
aProximate™ PTCs are primary cells derived from fresh human kidney tissue. They are grown on Transwells® and express the functional properties of a polarised cell layer with tight junctions.
In contrast to other models, aProximate™ PTCs retain high expression of the key renal transporters involved in drug handling including Megalin and Cubilin. Studies with aProximate™ give you a detailed mechanistic understanding of how drugs are transported and eliminated through the kidney. The model can be used to carryout drug-drug interaction studies to inform clinical trial design.
Available Analytical Readouts
- Flux and net transport measurements
- Measurement of intracellular drug and metabolite concentrations
- Identification of transporter-mediated drug-drug interactions
- Early renal damage biomarkers
- Cell viability