Why use our kidney transporter models?
Express all major renal transporters
Relevant results
Available to model most pre-clinical species
Predictive of human outcomes
Extensively validated for Drug-Drug Interactions (DDI) & nephrotoxicity
Reliable data
Kidney tissue models
aProximate™
aProximate™ is a validated, near physiological renal transporter model for use in drug transport and
Products
Human Primary Proximal tubule cells
Services using kidney transporter models
Drug drug interactions and (DDI)
- Drug transporter assay with primary proximal tubule cells (species: Human, rat, mouse and dog)
- Drug interactions assay with assay with primary proximal tubule cells (species: Human, rat, mouse and dog)
- Flux and net transporter measurements assay with primary proximal tubule cells (species: Human, rat, mouse and dog)
- Measurements of intracellular drug and metabolite concentrations assay with primary proximal tubule cells (species: Human, rat, mouse and dog)
Cross-species comparison
Kidney disease modelling
- Chronic kidney disease: Calcium and phosphate transporters imbalance with primary proximal tubule cells
- Metabolic diseases: Amino acid transporter impairment with primary proximal tubule cells
- Gout: Urate transporters deficiency with primary proximal tubule cells
Functional and efficacy studies
Newcells Offerings
Kidney Transporter Models Capabilities
Working with us
Timely service
Our ethical and secure primary tissue supply chain enables us to run studies and produce products to meet customers important and demanding timelines. We process multiple primary tissue every month meaning order-to-data response times can fit with the most demanding of customer deadlines. Our kidney transporter models, sometimes known as renal transporter models, are designed to support drug discovery and drug transport. At Newcells, we offer kidney transporter models, proximal tubule cells and organic anion transporters (OATs) to our customers to help them in their studies of the kidney. Our kidney models can provide support with understanding chronic kidney disease modelling, kidney toxicity and drug transporter interactions.
Validation of kidney transporter models
Our kidney transporter models are well characterised and rigorously validated to ensure the generation of robust and comparable data predictive of in vivo renal physiology. Our clients also value our scientific expertise supporting the experimental design of our kidney transporters as well as the analysis and interpretation of data.
How we support our clients
By providing predictive data on drug transporter interactions in the kidney, we give our clients confidence in their key decision processes using our renal transporter models. Our service enables identification of cross-species differences in renal drug handling, identification of clinically relevant transporter-mediated Drug-Drug interactions and assessment of drug-induced kidney damage.
Our expertise with kidney transporter models
Our team have an in-depth knowledge of kidney physiology and chronic kidney disease, cell-based models and assay development. They have designed and completed hundreds of studies on novel compounds using the unique kidney transporter models and provided interpreted data sets to customers to advance candidates into the clinic. Working under a QMS environment, the data and reports have been used to support regulatory submissions.
Contact us
If you are looking for kidney transporter models to support you work in drug discovery, drug interactions or drug transporters, our team of experts at Newcells are here to support you. Speak to one of our experts about your requirements today by contacting us.
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