A Primary Human in vitro Focal Segmental Glomerulosclerosis (FSGS) model for drug development applications

Focal Segmental Glomerulosclerosis (FSGS) is a common feature of Chronic Kidney Disease and is characterised by proteinuria and the deposition of extracellular matrix (scarring) of glomeruli. Drug-induced FSGS can be caused by Adriamycin, Daunorubicin, Pamidronate, and others, and leads to podocyte  death  and  loss ,  and  a  decrease  in Glomerular Filtration Barrier integrity. The clinical consequence of this is proteinuria, whereby essential proteins, including albumin, are  lost  from  the  blood  into  the urine.  FSGS is commonly studied using the Adriamycin Nephropathy mouse model; here we present an alternative in vitro model composed of freshly-derived human podocytes.

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