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New scientific publication in collaboration with the University of Newcastle on modelling Stargardt disease (STGD1) in vitro with retinal organoids (RO) to unravel genotype-phenotype correlations

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Cross species comparisons

aProximate™ as a novel, predictive model of aminoglycoside-induced nephrotoxicity

Keith Pye, Git Chung, Lyle Armstrong, Mike Nicholds, Colin Brown Abstracts of the 55th Congress of the European Societies of Toxicology (EUROTOX 2019) TOXICOLOGY SCIENCE PROVIDING SOLUTIONS. Toxicol Lett. 2019;314:S167–8.

A storyboard of renal transport

In vitro models for accurate prediction of renal tubular xenobiotic transport in vivo

Jelle Vriend, Keith R. Pye, Colin Brown. Current Opinion in Toxicology. 2021; 25: 15-22

Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity

Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity

Piyush Bajaj, Git Chung, Keith Pye, Tomoya Yukawa, Akio Imanishi, Yuichi Takai, Colin Brown, Matthew P.Wagoner
Toxicology. 2020; 442:152535

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Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling

Colin D. A. Brown, Rachel Sayer, Amy S Windass, Iain S Haslam, Marc E De Broe, Patrick C D’Haese, Anja Verhulst Toxicology and Applied Pharmacology. 2008; 233(3): 428-438

Newcells Biotech

Primary human proximal tubule cell monolayers as a predictive model of renal phosphate homeostasis in heath & disease

Colin D. A. Brown. Drug Metabolism and Pharmacokinetics. 2017; 32(1): S14-S15

Newcells Biotech

P52 – Determination of aminoglycoside toxicity in human renal proximal tubule monolayers using clinical relevant biomarkers of nephrotoxicity

Colin Brown, Lyle Armstrong, Mike Nicholds, Git Nicholds Drug Metabolism and Pharmacokinetics. 2020; 35(1):S37

Newcells Biotech

Characterization of cisplatin toxicity in aProximate™ human proximal tubule cell monolayers

Colin Brown, Git Chung, Lyle Armstrong, Mike Nicholds Drug Metabolism and Pharmacokinetics. 2019; 34(1): S52-S53; SOT 2019 P105

Newcells Biotech

Human primary proximal tubule cell monolayers as a novel predictive model of nephrotoxicity

Git Chung, Sarah Billington, R. D. Wilde, Colin Brown Toxicology Letters. 2016;258:S139-S140

Application of organoid technology for retinal disease modelling and drug discovery

Application of organoid technology for retinal disease modelling & drug discovery

Valeria Chichagova. Drug Target Review. June 2020.

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