Announcement:

New scientific publication in collaboration with the University of Newcastle on modelling Stargardt disease (STGD1) in vitro with retinal organoids (RO) to unravel genotype-phenotype correlations

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Resources: Case studies

Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro evaluation of ocular toxicity and phenotypic rescue

In vitro selection of the most relevant species to predict human renal toxicity

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Isolated primary podocytes immunostained for cilia

Evaluation of glomerular ADC toxicity in podocytes

Gene therapy viral vector assessment on retinal organoids

RPE

Gene therapy viral vector assessment on RPE cells

Predicting human renal injury from antisense oligonucleotide (ASO)

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