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The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression & function in the proximal tubule
Sarah E. Jenkinson, Git W Chung, Ellen van Loon, Nur S Bakar, Abigail M Dalzell, Colin D A Brown Pflügers Archiv European Journal of Physiology. 2012; 464(6): 601-11
Find out moreThe breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane
M. Huls, C D A Brown, A S Windass, R Sayer, J J M W van den Heuvel, S Heemskerk, F G M Russel, R Masereeuw Kindey International. 2008; 73(2): 220-5
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In vitro platforms for de-risking nephrotoxicity during drug development
Dr Sandy Primrose & Dr Colin Brown Drug Target Review. March 2020
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An inter-species comparison of the triclopyr in vitro and in vivo toxicokinetic properties, for risk assessment purpose
The aProximate™ in vitro renal proximal tubule cell model as a platform to investigate the renal uptake and nephrotoxic liability of biologics
Improved in vitro renal tubular drug transport modelling to meet challenges
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Case Studies
View allQuantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
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In vitro evaluation of ocular toxicity and phenotypic rescue
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In vitro selection of the most relevant species to predict human
Evaluation of glomerular ADC toxicity in podocytes
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Gene therapy viral vector assessment on retinal organoids
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Gene therapy viral vector assessment on RPE cells
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