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Derivation of a system-independent Ki for p-glycoprotein mediated digoxin transport from system-dependent IC50 data
Aqsaa Chaudhry, Git Chung, Adam Lynn, Akshata Yalvigi, Colin Brown, Harma Ellens, Michael O’Connor, Caroline Lee, Joe Bentz Drug Metabolism and Disposition. 2018; 46(3): 279-290
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Abundance of drug transporters in the human kidney cortex as quantified by quantitative targeted proteomics
Bhagwat Prasad, Katherine Johnson, Sarah Billington, Caroline Lee, Git W Chung, Colin D A Brown, Edward J Kelly, Jonathan Himmelfarb, Jashvant D Unadkat Drug Metabolism and Disposition. 2018; 46(3): 279-290
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The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression & function in the proximal tubule
Sarah E. Jenkinson, Git W Chung, Ellen van Loon, Nur S Bakar, Abigail M Dalzell, Colin D A Brown Pflügers Archiv European Journal of Physiology. 2012; 464(6): 601-11
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Development of predictive in vitro cross-species proximal tubule models for nephrotoxicity studies
An inter-species comparison of the triclopyr in vitro and in vivo toxicokinetic properties, for risk assessment purpose
The aProximate™ in vitro renal proximal tubule cell model as a platform to investigate the renal uptake and nephrotoxic liability of biologics
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Case Studies
View allQuantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
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In vitro evaluation of ocular toxicity and phenotypic rescue
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In vitro selection of the most relevant species to predict human
Evaluation of glomerular ADC toxicity in podocytes
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Gene therapy viral vector assessment on retinal organoids
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Gene therapy viral vector assessment on RPE cells
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Predicting human renal injury from antisense oligonucleotide (ASO)
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