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Scientific Publications
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Human-induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient-dependent efficiency
Stem Cells. 2018; 36(10):1535-1551
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Using statistical models to identify key variables critical for generation of retinal organoids from iPSC
Valeria Chichagova, Dean Hallam, Mike Nicholds, Robert Thomas, Majlinda Lako, Lyle Armstrong Investigative Ophthalmology & Visual Science. 2018; 59(9): 565
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Derivation of a system-independent Ki for p-glycoprotein mediated digoxin transport from system-dependent IC50 data
Aqsaa Chaudhry, Git Chung, Adam Lynn, Akshata Yalvigi, Colin Brown, Harma Ellens, Michael O’Connor, Caroline Lee, Joe Bentz Drug Metabolism and Disposition. 2018; 46(3): 279-290
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Development of predictive in vitro cross-species proximal tubule models for nephrotoxicity studies
An inter-species comparison of the triclopyr in vitro and in vivo toxicokinetic properties, for risk assessment purpose
The aProximate™ in vitro renal proximal tubule cell model as a platform to investigate the renal uptake and nephrotoxic liability of biologics
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Case Studies
View allAnalysis of the effect of a compound on retinal microtissue composition
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Development of a human in vitro model for retinitis pigmentosa
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Assessing the validity of a nephron model for a metabolic disease study
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DDI study on renal creatinine clearance mechanism
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Predicting renal retention of radioconjugates in a human relevant in vitro model
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Safety and efficacy evaluation of a novel therapeutic AAV vectors using a human retinal organoid model
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Comparing the transduction efficiency of two AAV vectors in RPE and Retinal Organoid models derived from iPSC lines
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Comprehensive toxicity study on retinal ganglion cells in early-stage human retinal organoids
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Development and characterisation of an early-stage retinal organoid disease model (for non-ocular disease)
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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
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Comprehensive in vitro evaluation of ocular toxicity and phenotypic rescue
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In vitro selection of the most relevant species to predict human
Evaluation of glomerular ADC toxicity in podocytes
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Gene therapy viral vector assessment on retinal organoids
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Gene therapy viral vector assessment on RPE cells
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Predicting human renal injury from antisense oligonucleotide (ASO)
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