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Scientific Publications

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Newcells Biotech

Using statistical models to identify key variables critical for generation of retinal organoids from iPSC

Valeria Chichagova, Dean Hallam, Mike Nicholds, Robert Thomas, Majlinda Lako, Lyle Armstrong Investigative Ophthalmology & Visual Science. 2018; 59(9): 565

Derivation of a system-independent Ki for p-glycoprotein mediated digoxin transport from system-dependent IC50 data

Derivation of a system-independent Ki for p-glycoprotein mediated digoxin transport from system-dependent IC50 data

Aqsaa Chaudhry, Git Chung, Adam Lynn, Akshata Yalvigi, Colin Brown, Harma Ellens, Michael O’Connor, Caroline Lee, Joe Bentz Drug Metabolism and Disposition. 2018; 46(3): 279-290

Abundance of drug transporters in the human kidney cortex as quantified by quantitative targeted proteomics

Bhagwat Prasad, Katherine Johnson, Sarah Billington, Caroline Lee, Git W Chung, Colin D A Brown, Edward J Kelly, Jonathan Himmelfarb, Jashvant D Unadkat Drug Metabolism and Disposition. 2018; 46(3): 279-290

Posters

Complementary in vitro tools to investigate renal drug transport

Development of a predictive in vitro human proximal tubule platform for de-risking nephrotoxicity

Development of predictive in vitro cross-species proximal tubule models for nephrotoxicity studies

Fact Sheets

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Press releases

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Scientific eBooks and Protocols

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Q&A with our scientists

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Videos and Webinars

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Case Studies

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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A microscope image of a nephron model

Evaluation of glomerular ADC toxicity in podocytes

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Gene therapy viral vector assessment on retinal organoids

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Gene therapy viral vector assessment on RPE cells

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RPE