An in-vitro high-content imaging assay for the study of fibroblast activation and matrix deposition

Idiopathic Pulmonary Fibrosis (IPF) is a chronic and progressive interstitial lung disease, whereby damage to the lung architecture leads to an irreversible loss of function.

The aetiology of IPF is unknown, but is thought to occur due to epithelial damage, abnormal epithelial-fibroblast communication, and subsequent dysregulated tissue repair response.