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Latest Publication: Read our teams’ latest paper in Antibiotics, showing reduced nephrotoxicity of a novel formulation of polymyxin B compared to the clinical formulation using a validated primary human proximal tubule cell model.

An in vitro model that predicts Antibiotic Renal Toxicity

Antimicrobial resistance is a potentially catastrophic global issue that has the potential to cripple our ability to carry out even the simplest medical interventions. To combat this issue, we need to develop more comprehensive ways of screening antibiotics for potential renal toxicity. Our In vitro kidney model utilises freshly isolated Human proximal tubular cells (PTC) seeded out on 96-well Transwells™ that accurately express phenotypic receptor expression levels of in vivo kidneys


20th March, 2024

Published by

Jamie Jordan, Keith Pye, Kathryn Garner and Colin Brown

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