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Latest Publication: Read our teams’ latest paper in Antibiotics, showing reduced nephrotoxicity of a novel formulation of polymyxin B compared to the clinical formulation using a validated primary human proximal tubule cell model.

A predictive in vitro primary proximal tubule platform for derisking of antibiotic-induced kidney injury

Our innovative solution consists of highly differentiated assays using primary renal proximal tubule cells (PTCs) derived from key animal species to measure drug transport and drug induced kidney injury to predict nephrotoxicity for human clinical trials.
In this poster, we showcase data relating to in vitro safety testing of antibiotics demonstrating the use of our platform as a powerful tool to prevent antibiotics induced kidney injury.


9th February, 2024

Published by

Colin Brown et al.

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