Comparison of multiple batches of human iPSC-derived retinal organoids produced at large scale

Due to well-known limitations of in vivo and existing in vitro retinal models, a 3D in vitro model of the human retina which is reproducible and able to accurately predict in vivo outcomes is highly desirable

Our aim was to investigate the consistency of human iPSC-derived retinal organoids (RO) produced at large scale by quantifying the gene and protein expression levels of key retinal cell markers across differentiation in multiple batches.