The aProximate™ in vitro renal proximal tubule cell model as a platform to investigate the renal uptake & nephrotoxic liability of Antisense Oligonucleotide drug molecules

Many biologics accumulate in the kidney and may cause unforeseen kidney injury. Currently there is no in vitro platform that enables cross-species comparisons of drug transport or
nephrotoxicity.

Our innovative solution is to develop highly differentiated assay platforms using primary renal proximal tubule cells (PTCs) derived from key animal species to measure both drug transport and drug induced kidney injury a range of biomarkers across species. Here we showcase data from our highly differentiated Human Primate proximal tubule model showing its utility in the study of biologics.