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Latest Publication: Read our teams’ latest paper in Antibiotics, showing reduced nephrotoxicity of a novel formulation of polymyxin B compared to the clinical formulation using a validated primary human proximal tubule cell model.

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Resources: Scientific publications - Page 2

Newcells Biotech

Characterization of cisplatin toxicity in aProximate™ human proximal tubule cell monolayers

Colin Brown, Git Chung, Lyle Armstrong, Mike Nicholds Drug Metabolism and Pharmacokinetics. 2019; 34(1): S52-S53; SOT 2019 P105

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Development of a novel predictive in vitro non human primate proximal tubule model for drug transporter & nephrotoxicity studies

Colin Brown Drug Metabolism and Pharmacokinetics. 2019; 34(1):S53

Cross species comparisons

aProximate™ as a novel, predictive model of aminoglycoside-induced nephrotoxicity

Keith Pye, Git Chung, Lyle Armstrong, Mike Nicholds, Colin Brown Abstracts of the 55th Congress of the European Societies of Toxicology (EUROTOX 2019) TOXICOLOGY SCIENCE PROVIDING SOLUTIONS. Toxicol Lett. 2019;314:S167–8.

Application of organoid technology for retinal disease modelling and drug discovery

Application of organoid technology for retinal disease modelling & drug discovery

Valeria Chichagova. Drug Target Review. June 2020.

A storyboard of renal transport

In vitro models for accurate prediction of renal tubular xenobiotic transport in vivo

Jelle Vriend, Keith R. Pye, Colin Brown. Current Opinion in Toxicology. 2021; 25: 15-22

Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity

Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity

Piyush Bajaj, Git Chung, Keith Pye, Tomoya Yukawa, Akio Imanishi, Yuichi Takai, Colin Brown, Matthew P.Wagoner
Toxicology. 2020; 442:152535

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Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling

Colin D. A. Brown, Rachel Sayer, Amy S Windass, Iain S Haslam, Marc E De Broe, Patrick C D’Haese, Anja Verhulst Toxicology and Applied Pharmacology. 2008; 233(3): 428-438

Newcells Biotech

P52 – Determination of aminoglycoside toxicity in human renal proximal tubule monolayers using clinical relevant biomarkers of nephrotoxicity

Colin Brown, Lyle Armstrong, Mike Nicholds, Git Nicholds Drug Metabolism and Pharmacokinetics. 2020; 35(1):S37

Newcells Biotech

c-Rel orchestrates energy-dependent epithelial & macrophage reprogramming in fibrosis

Nature Metabolism. 2020; 2:1350–1367