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5th Chronic Kidney Disease Drug Development Summit


7th March 2023 - 9 March, 2023


Hilton Boston Logan Airport Hotel


Boston, MA

Presented by

Dr Kathryn Garner

The CKD Drug Development Summit is uniquely positioned to de-risk drug development in cardiorenal disorders and provide strategic insight into paving the way to regulatory approval.

Dr Kathryn Garner will be presenting the following talk:

Primary kidney cells for modelling Chronic Kidney Disease in vitro

• Human podocytes maintain high levels of key podocyte markers, including nephrin, podocin, WT1, CD2AP.
• Well-validated Podocyte Toxicity Assay senses injury through barrier integrity (TEER) measures and passage of fluorescently-labelled dextran molecules.
• Disease modelling in podocytes, proximal tubule cells and renal fibroblasts with monitoring of fibrosis readouts – matrix deposition – using high content imaging.

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CKD Summit Chronic Kidney Disease Drug Development

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