Our latest paper in collaboration with Pfizer on the role of OCT2/MATE in creatinine clearance is accepted in JPET.
The proximal tubules of the kidney nephron play a key role in the reabsorption of filtered amino acids, glucose, solutes, and low molecular weight proteins, such as albumin, from the tubular filtrate. Many xenobiotics are also reabsorbed here, which if not rapidly cleared from the cells, can cause nephrotoxicity.
20th September, 2023
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