Our latest paper in collaboration with Pfizer on the role of OCT2/MATE in creatinine clearance is accepted in JPET.
aProximate™ is a highly sophisticated, near-physiological proximal tubule cell (PTC) model that is a proven market-leader in the study of transporters and drug-drug interactions.
One issue with primary cell cultures is the short time window they remain differentiated and functional, which has hindered the sharing of primary cell models between laboratories.
To overcome this and ship cells globally in an assay-ready format, a safe and reliable short-term preservation method was developed and internally validated, pausing cells at hypothermic temperatures for up to 5 days.
24th January, 2023
Lucy Gentles, Claire Devlin, Cindy Carr, Colin Brown
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