Our latest paper in collaboration with Pfizer on the role of OCT2/MATE in creatinine clearance is accepted in JPET.
The proximal tubule (PT) is the key nephron segment mediating renal drug elimination and is the primary site of drug induced nephrotoxicity.
However, current animal studies have proved poorly predictive of human outcome. To address this, there has been a recent upsurge in physiological relevant microphysiological systems (MPS) of PT to recapitulate differentiation and function in vitro. Here we present results from our recently developed aProximate MPS™ human PT platform (Patent No: G001336.GB), in which primary human PT cells are subject to fluidic media flow and a shear stress between 0.1-2 dynes/cm².
19th January, 2023
Donovan O’Brien, Francesca Pisapia, Elena Tasinato, Kathryn Garner and Colin Brown
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