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Scientific Publications
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Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling
Colin D. A. Brown, Rachel Sayer, Amy S Windass, Iain S Haslam, Marc E De Broe, Patrick C D’Haese, Anja Verhulst Toxicology and Applied Pharmacology. 2008; 233(3): 428-438
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In vitro models for accurate prediction of renal tubular xenobiotic transport in vivo
Jelle Vriend, Keith R. Pye, Colin Brown. Current Opinion in Toxicology. 2021; 25: 15-22
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Development of a novel predictive in vitro non human primate proximal tubule model for drug transporter & nephrotoxicity studies
Colin Brown Drug Metabolism and Pharmacokinetics. 2019; 34(1):S53
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A high-throughput, in vitro assessment of antibiotic induced podocyte injury
A Primary Human in vitro Focal Segmental Glomerulosclerosis (FSGS) model for drug development applications
An in vitro Human Primary Thick Ascending Limb Model For The Assessment of Compound Nephrotoxicity
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Case Studies
View allAnalysis of the effect of a compound on retinal microtissue composition
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Development of a human in vitro model for retinitis pigmentosa
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Assessing the validity of a nephron model for a metabolic disease study
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DDI study on renal creatinine clearance mechanism
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Predicting renal retention of radioconjugates in a human relevant in vitro model
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Safety and efficacy evaluation of a novel therapeutic AAV vectors using a human retinal organoid model
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Comparing the transduction efficiency of two AAV vectors in RPE and Retinal Organoid models derived from iPSCs lines
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Comprehensive toxicity study on retinal ganglion cells in early-stage human retinal organoids
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Development and characterisation of an early-stage retinal organoid disease model (for non-ocular disease)
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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
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Comprehensive in vitro evaluation of ocular toxicity and phenotypic rescue
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In vitro selection of the most relevant species to predict human
Evaluation of glomerular ADC toxicity in podocytes
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Gene therapy viral vector assessment on retinal organoids
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Gene therapy viral vector assessment on RPE cells
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Predicting human renal injury from antisense oligonucleotide (ASO)
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