Resources
Scientific Publications
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Application of organoid technology for retinal disease modelling & drug discovery
Valeria Chichagova. Drug Target Review. June 2020.
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Enhancing immune function of hiPSC-derived retinal organoids by incorporating microglial cells
Valeria Chichagova, Maria Georgiou, Birthe Dorgau, Madeleine Carter, Git Chung, Evelyne Sernagor, Lyle Armstrong, Majlinda Lako Investigative Ophthalmology & Visual Science. 2020; 61(7)
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Room temperature shipment does not affect the biological activity of pluripotent stem cell derived retinal organoids
Maria Georgiou et al. PLoS ONE. 2020; 15(6), e0233860.
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Scientific eBooks and Protocols
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Case Studies
View allAnalysis of the effect of a compound on retinal microtissue composition
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Development of a human in vitro model for retinitis pigmentosa
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Assessing the validity of a nephron model for a metabolic disease study
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DDI study on renal creatinine clearance mechanism
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Predicting renal retention of radioconjugates in a human relevant in vitro model
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Safety and efficacy evaluation of a novel therapeutic AAV vectors using a human retinal organoid model
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Comparing the transduction efficiency of two AAV vectors in RPE and Retinal Organoid models derived from iPSCs lines
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Comprehensive toxicity study on retinal ganglion cells in early-stage human retinal organoids
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Development and characterisation of an early-stage retinal organoid disease model (for non-ocular disease)
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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
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Comprehensive in vitro evaluation of ocular toxicity and phenotypic rescue
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In vitro selection of the most relevant species to predict human
Evaluation of glomerular ADC toxicity in podocytes
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Gene therapy viral vector assessment on retinal organoids
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Gene therapy viral vector assessment on RPE cells
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Predicting human renal injury from antisense oligonucleotide (ASO)
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