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Scientific Publications

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Human iPSC differentiation to retinal organoids.

Human iPSC differentiation to retinal organoids in response to IGF1 and BMP4 activation is line- & method-dependent

Valeria Chichagova, Gerrit Hilgen, Ali Ghareeb, Maria Georgiou, Madeleine Carter, Evelyne Sernagor, Majlinda Lako, Lyle Armstrong Stem Cells. 2020; 38(2):195-201

Newcells Biotech

Differentiation of retinal organoids from human pluripotent stem cells

Valeria Chichagova, Birthe Dorgau, Majed Felemban, Maria Georgiou, Lyle Armstrong, Majlinda Lako Current Protocols in Stem Cell Biology. 2019; 50(1):e95

Diagrammatic representation of the culture formats for both single and pooled retinal organoids

Human-induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient-dependent efficiency

Stem Cells. 2018; 36(10):1535-1551

Posters

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White Papers

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Fact Sheets

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Press releases

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Scientific eBooks and Protocols

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Q&A with our scientists

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Videos and Webinars

Retinal organoids as a tool for in vitro pre-clinical testing

Retinal Organoids as an Emerging Tool for Drug Discovery

NIH/NEI 3D-ROC Sponsor Webinar

NIH/NEI 3D-ROC Sponsor Webinar

Case Studies

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Safety and efficacy evaluation of a novel therapeutic AAV vectors using a human retinal organoid model

Evaluation of a novel therapeutic AAV vectors

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Comparing the transduction efficiency of two AAV vectors in RPE and Retinal Organoid models derived from iPSCs lines

Comparing the transduction efficiency of two AAV vectors

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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Evaluation of glomerular ADC toxicity in podocytes

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Isolated primary podocytes immunostained for cilia

Gene therapy viral vector assessment on retinal organoids

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Gene therapy viral vector assessment on RPE cells

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RPE

Predicting human renal injury from antisense oligonucleotide (ASO)

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