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Resources

Scientific Publications

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Newcells Biotech

The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression & function in the proximal tubule

Sarah E. Jenkinson, Git W Chung, Ellen van Loon, Nur S Bakar, Abigail M Dalzell, Colin D A Brown Pflügers Archiv European Journal of Physiology. 2012; 464(6): 601-11

Posters

The aProximate™ in vitro renal proximal tubule cell model as a platform to investigate the renal uptake & nephrotoxic liability of Antisense Oligonucleotide drug molecules

A solution for shipping primary human proximal tubule cell monolayers between laboratories

Development of highly-differentiated human primary proximal tubule MPS model

Fact Sheets

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Press releases

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Scientific eBooks and Protocols

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Q&A with our scientists

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Videos and Webinars

Dr Colin Brown

The Kidney as a Therapeutic Target: Targeting Therapeutics to the Proximal Tubule

Reducing compound attrition by predicting renal tubular toxicity with in vitro PTEC models

Reducing compound attrition by predicting renal tubular toxicity with in vitro PTEC models

Case Studies

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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A microscope image of a nephron model

Evaluation of glomerular ADC toxicity in podocytes

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Gene therapy viral vector assessment on retinal organoids

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Gene therapy viral vector assessment on RPE cells

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RPE