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Our latest paper in collaboration with Pfizer on the role of OCT2/MATE in creatinine clearance is accepted in JPET.

Primary Kidney Cells for Modelling Chronic Kidney Disease in vitro


March 28, 2023

Presented by

Dr Kathryn Garner, PhD

  • Human podocytes maintain high levels of key podocyte markers, including nephrin, podocin, WT1, CD2AP.
  • Well-validated Podocyte Toxicity Assay senses injury through barrier integrity (TEER) measures and passage of fluorescently-labelled dextran molecules.
  • Disease modelling in podocytes, proximal tubule cells and renal fibroblasts with monitoring of fibrosis readouts – matrix deposition – using high content imaging.

Find out more about our glomerulus model and kidney toxicity assays

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