Updates - Page 2
In vitro models for chronic kidney disease (CKD)
Phosphate balance is central to many metabolic pathways, and the kidneys play a key role in the reabsorption and excretion of phosphate to achieve this balance. In CKD, however,…
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NB collaborates with Takeda Pharmaceuticals on renal drug safety evaluation study
Newcells Biotech and Takeda Pharmaceutical International Co. have collaborated in a study designed to assess drug safety. The study evaluated a set of 36 known drugs and…
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Developing a 3D in vitro proximal tubule model for chronic toxicity studies
The kidney proximal tubule is of key interest in drug discovery. This is due to its primary role in the excretion and reabsorption of xenobiotics, such as drugs and…
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Improved in vitro renal tubular drug transport modelling to meet regulatory & development cost challenges
The proximal tubule is key due to its role in the excretion and reabsorption of many xenobiotic compounds. Due to the high costs associated with drug discovery and the…
Read updateBiologics & the kidney – importance of transport & safety assessment
Biologics represent a new modality of drug molecules which is rapidly expanding in market share and in the number of biologics gaining regulatory approval each year. Biologics are defined…
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Renal drug handling and drug-drug interactions in ADMET
The assays currently offered are based on human or animal cells transfected to express single or dual human kidney transporters on their surfaces. The major limitation is that they…
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